Description
Cagrilinitide (or “Cagri”) is a long-acting, lipidated, albumin-binding amylin agonist that targets both amylin and calcitonin receptors. It is used in the treatment of obesity, either on its own or in combination with GLP-1 receptor agonists. Amylin is co-secreted with insulin from pancreatic beta cells and regulates appetite, satiety, gastric emptying, and glucose control.
Combining Cagrilinitide with a GLP-1 like Semaglutide has a synergistic effect, amplifying weight loss beyond what either peptide achieves independently. Other benefits include improved circulation, reduced blood pressure, enhanced bone-building activity, and vasodilation.
Outcomes
- 6–10% body weight loss at 26 weeks (Cagrilinitide alone)
- 23–24.4% body weight loss at 68 weeks (combined with Semaglutide)
- Synergistic effect: up to 8% more weight loss vs. Semaglutide alone
Possible Side Effects
- Injection site reaction (redness, swelling, itching, hives)
- Nausea
- Vomiting
- Constipation
- Fatigue
- Headache
- Diarrhea
- Heartburn
- Gallbladder stones (rare)
Dosing
CAGRILINITIDE: 10MG
Mix with 2mL (200 units) of BAC water
Subcutaneous Administration
16-week cycle followed by a 4–6 week washout period
- Week 1: 8 units (400mcg)
- Weeks 2 & 3: 15 units (750mcg)
- Weeks 4 & 5: 24 units (1.2mg)
- Weeks 6 & 7: 34 units (1.7mg)
- Weeks 8 & 9: 44 units (2.2mg)
- Weeks 10-16: 54 units (2.7mg)
Important Notes
- Always dose on the same day each week
- Ensure adequate hydration throughout the cycle
- Do not exceed 16 consecutive weeks of use
- Anti-Cagri antibodies may form with extended use (46–73% of users)
Stacking Suggestions
- Semaglutide or Tirzepatide – Boosts appetite suppression and fat loss via GLP-1 synergy
- Tesofensine – Enhances energy expenditure and thermogenesis
- L-Carnitine – Supports fat metabolism and energy conversion
- AOD-9604 – Encourages lipolysis and body fat reduction without affecting blood sugar
All peptide instructions on this site are provided strictly for laboratory research and educational purposes. This information is not intended for human or veterinary use unless prescribed by a licensed medical professional.
