Description
Tirzepatide was originally developed to treat Type-2 diabetes but has since become a leading anti-obesity medication. It is a dual agonist of the GLP-1 and GIP receptors — meaning it activates two distinct hormonal pathways to reduce appetite, improve metabolic rate, and support sustained weight loss. Unlike its predecessor Semaglutide (which only targets GLP-1), Tirzepatide showed 5–7% more weight loss in clinical trials. Compared to Retatrutide, a triple agonist, Tirzepatide accomplished nearly the same weight loss but over a longer period (72 weeks vs. 48).
Mechanism of Action
- GLP-1: Suppresses appetite and increases feelings of fullness after eating.
- GIP: Promotes insulin secretion and supports energy balance through receptors in the hypothalamus.
Benefits
- Average weight loss of 24.7% after 72 weeks
- Reduces appetite and cravings
- Enhances satiety and energy balance
- Supports fat oxidation and metabolism
- Improves insulin sensitivity and blood sugar control
Possible Side Effects (often mild and temporary; affected only ~25% in trials)
- Injection site reaction (redness, swelling, itching)
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Decreased appetite
- Fatigue
- Dyspepsia (indigestion)
- Abdominal pain
- Burping (may have sulfur smell)
- Hair loss
Rare but serious risks
- Thyroid C-Cell Tumors
- Pancreatitis
- Gastroparesis (stomach paralysis)
- Hypoglycemia (if used with insulin)
- Gallbladder disease
- Kidney issues (linked to dehydration)
- Pulmonary aspiration under anesthesia – ALWAYS disclose Tirzepatide use to surgical teams
Contraindications
Do not use if pregnant or breastfeeding
- Do not use with a personal or family history of Medullary Thyroid Carcinoma or MEN 2 (Multiple Endocrine Neoplasia)
- Do not use if you have Type-1 diabetes, diabetic retinopathy, or severe GI disease
- Do not use if you are allergic or hypersensitive to Tirzepatide
TIRZEPATIDE: 10MG
Mix with 0.5mL (50 units) of BAC water
Dose 1 day of each week (once every 7 days), always on the same day of the week. Stay on each dose for a minimum of 4 weeks before raising to the next dose
Subcutaneous Dosing
*Please note that those who are transferring to Tirzepatide from another GLP peptide, your starting dose is 5mg, NOT 2.5mg
2.5mg = 12 units
5 mg = 25 units
7.5mg = 38 units
10mg = 50 units
TIRZEPATIDE: 30MG
Mix with 1.5mL (150 units) of BAC water
Dose 1 day of each week (once every 7 days), always on the same day of the week. Stay on each dose for a minimum of 4 weeks before increasing
Subcutaneous Dosing
*Please note that those who are transferring to Tirzepatide from another GLP peptide, your starting dose is 5mg, NOT 2.5mg
2.5mg = 12 units
5 mg = 25 units
7.5mg = 38 units
10mg = 50 units
12.5mg = 62 units
15mg = 75 units
TIRZEPATIDE: 60MG Mix with 3mL (300 units) of BAC water
Dose 1 day of each week (once every 7 days), always on the same day of the week. Stay on each dose for a minimum of 4 weeks before increasing
Subcutaneous Dosing
*Please note that those who are transferring to Tirzepatide from another GLP peptide, your starting dose is 5mg, NOT 2.5mg
2.5mg = 12 units
5 mg = 25 units
7.5mg = 38 units
10mg = 50 units
12.5mg = 62 units
15mg = 75 units
Stacking Suggestions
- AOD-9604 – enhances fat breakdown and further accelerates weight loss alongside appetite suppression
- Tesamorelin – synergistic for fat reduction, especially visceral fat and metabolic regulation
- Semax or Selank – manage mood and cognitive function while adjusting to appetite changes
- NAD+ or MOTS-C – support energy, mitochondrial efficiency, and metabolism while on a caloric deficit
- BPC-157 – beneficial for gut repair if experiencing nausea, indigestion, or stomach discomfort
- CJC-1295 / Ipamorelin – for muscle maintenance and enhanced metabolic recovery while losing fat
All peptide instructions on this site are provided strictly for laboratory research and educational purposes. This information is not intended for human or veterinary use unless prescribed by a licensed medical professional.
